Endocrine Abstracts

A 21-year old male with a 4 year history of tip 1 diabetes mellitus was admitted for diabetic ketoasidosis. The patient was on premixed insulin in two divided of 20 units. He had poor control of diabetes with no regular follow up. His height was 141 cm (3rd persentile), and weight was 36 kg (3rd percentile). These anthropometric findings demonstrated low-height for his age. His bone age was consisted with 16 years. Physical examination revealed moon face, hepatomegaly, short s...

Introduction: The differential diagnosis between Graves’ disease (GD) and gestational transient thyrotoxicosis (GTT) is difficult in the absence of history and clinical features of GD. In this study, we aimed to determine the role of peak systolic (PSV) and end-diastolic velocities (EDV) of the right and left inferior thyroid arteries (ITA) as measured by color-flow Doppler ultrasonography (CFDUSG) for discriminating GTT from treatment naive GD.Meth...

Background: Obesity and diabetes mellitus (DM) are the features of Cushing’s disease (CD). Studies indicated different frequencies of CD among obese, type 2 DM patients. The frequency of CD among obese, type 2 DM have’nt been studied in Turkey. Therefore, we aimed to assess the frequency of CD among obese (BMI>30 kg/m2) type 2 DM patients that had not classical morphological findings of CD.Patients and methods: Two hundred consec...

Background: Acromegaly is a multi-systemic dysfiguring disease caused by pituitary GH secreting tumour. Pituitary surgery, medical treatment with somatostatin analogues and radiotherapy have been cornerstone in the management of acromegaly. However, all these treatment modalities do not provide sufficient disease control especially in patients with macroadenomas.Objective: To evaluate the follow-up outcomes and remission rates of acromegaly patients....

Introduction: Recent conducted studies show that clinical hypothyroidism (CH) has similar cardiovascular risk with subclinical hypothyroidism (SCH). Carotid intima media thickness (CIMT) that is an important marker of early atherosclerotic changes is an indicator of cardiovascular events. In our study, we evaluated CIMT in female patients, who have both CH and SCH, with similar age and demographic features.Materials and methods: We recruited 38 healthy f...

Background: Currently, it is reported that statins may be useful in the treatment of DM foot ulceration1. The aim of the study was to evaluate treatment with topical atorvastatin of the wounds of streptozotocine induced diabetic rats.Materials and methods: Fifteen×fifteen mm sized wound were created in streptozotocin-induced rats. A total of twenty-eight diabetic rats were studied in 4 groups (n: 28). Any treatment was not administ...

Acromegaly is known to be associated with insulin resistance. Visceral adipose tissue is increased in patients with insulin resistance and we aimed to investigate a visceral adipose tissue content as a possible marker of insulin resistance in diabetic and nondiabetic acromegalic patients. We compared 16 diabetic and 16 nondiabetic acromegalic patients for fasting blood glucose (FBG), insulin and visceral adipose tissue content calculated from abdominal computer tomography. All...

Acromegaly is known to be associated with both increased cardiovascular mortality and carbohydrate intolerance. The aim of our study is to compare intima-media thickness, a marker of atherosclerosis in active acromegalic patients with and without diabetes. 32 active acromegalic patients (M/ F: 15/17, 16 diabetic and 16 nondiabetic) were assessed for fasting blood glucose (FBG), insulin, growth hormone, insulin-like growth factor 1 and carotid intima-media thickness (IMT). Diab...

Increased heel pad thickness can be used as a marker of soft tissue enlargement in acromegalic patients. We aimed to investigate if concomittant hyperinsulinemia/and or diabetes secondary to insulin resistance in acromegaly contribute to the enlargement of heel pad. We compared heel pad thickness in 16 diabetic and 16 nondiabetic active acromegalic patients using X-ray images. All of the diabetics were well controlled with diet and/ or oral antidiabetic drugs. GH and IGF-1 wer...

Aim: Subclinical Hypothyroidism (SH) is associated with cardiovascular disorders which may include increased risk for atherosclerosis, endothelial dysfunction and myocardial dysfunction.To investigate the prevalence of left ventricular systolic and diastolic dysfunction in patients with subclinical hypothyroidism and the effect of L-thyroxin therapy on myocardial performance using conventional echocardiographic parameters.Method: The study includes 95 pa...